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M94A3043.TXT
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1994-10-25
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Document 3043
DOCN M94A3043
TI p24 antibody level as a prognostic marker in HIV infection.
DT 9412
AU Ghioni G; Fernandez E; Viglianco R; Bortolozzi R; Taborda M; Fay O;
Center for technology in Public Health, National University of; Rosario
Argentina.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):167 (abstract no. PB0096). Unique
Identifier : AIDSLINE ICA10/94369532
AB OBJECTIVE: To evaluate the pronostic usefulness of p24 Ab cuantitation
in HIV infection. MATERIAL AND METHODS: 61 patients HIV positive were
included. Anti p24 from Boehringer Mannheim was ran. We used: Elisa test
from Organon Teknika and Abbott Laboratories; confirmatory test from
Organon Teknika (Western Blot and LiaTek), HIV antigen (with previous
acid disociation) from Abbott Laboratories and CD4/CD8 count by IFA,
using Boehringer Mannheim Antibody. RESULTS: In 15 (25%) out of 61
patients the HIV Ag was positive, with a rate of 290 U/ml (50 to 550
U/ml) anti P24 Ab < or = 7 U/ml and the rate of CD4 527/mm3 (97 to
952/mm3) and CD8 793/mm3 (199 to 1523/mm3). In 46 (75%) patients the HIV
Ag was negative. 30 (65%) have Anti HIV Ab titer < or = 7.0 U/ml with
CD4 rate 503/mm3 (70 to 866/mm3) and CD8 742/mm3 (211 to 1441/mm3). In
16 (35%) The Anti P24 Ab was > or = 66.0 (66 to 156/mm3) with a CD4
count 784/mm3 (630 to 1309mm3) and CD8 909/mm3 (642 to 1496mm3). Table I
shows the comparative results of different markers. DISCUSSION AND
CONCLUSIONS: 1) Anti p24 Ab seems to be a more releable marker than
CD4/CD8 and HIV Ag (p < 0.05) in the progression of HIV infection.
Whereas CD4/CD8 count remain stable, the HIV Ag level is not
significative statistically (p < 0.05). 2) The balance between the
shyntesys of antibody by the immune sistem and its role as a
neutralizing antibody apparently has direct influence in the level of
Anti HIV p24 Ab. TABULAR DATA, SEE ABSTRACT VOLUME.
DE Blotting, Western CD4-CD8 Ratio Enzyme-Linked Immunosorbent Assay
Human HIV Antibodies/*BLOOD HIV Antigens/BLOOD HIV Core Protein
p24/*IMMUNOLOGY HIV Infections/*DIAGNOSIS/IMMUNOLOGY HIV
Seropositivity/DIAGNOSIS/IMMUNOLOGY Leukocyte Count Prognosis T4
Lymphocytes/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).